Based in the Unhallowed Metropolis setting, London 2105 places the player in, of course, London in the year 2105. In 1905, The Plague, a sickness that turns the victim into a ravenous zombie after death, nearly destroyed the world. Fast Forward 200 years and humanity has retaken a small part of what they lost, but the sickness still haunts the population. You play as Lucard, an elite member of the fraternity of the Undertakers, the freelance bounty hunters who help keep the city clean of the undead scourge. Faced with not only the menace of the undead, he will uncover a foul corruption spreading through humanity that will lead to a truth that could undermine all of human civilization.