Blood Ties follows Annie, a young girl who suddenly finds herself alone in her childhood home. All the usual bumps, creaks, and weather sounds start to get to her, but she finds comfort in her friend Teddy. The horror of the situation quickly escalates, however, when she discovers that things are moving and changing on their own. Annie searches the house for her family and clues as to where they might have gone should she find them missing from the home. What she finds, however, was completely unexpected.