[RMVX ACE] [RM2K3] [RM2K] KEYS CRAPPING OUT WHEN GAMES ARE OPEN

Does anyone else have this weird problem with any rpg maker, where the ESC, 0, numpad 0, and X keys just stop working all together? It seems like it happens when the game is open for too long. Like what is it doing?? It decides, kinda strangely, where the keys just crap out and when I restart my computer, it works fine. It's the weirdest thing and I don't know what it's doing.