I don't care either way, really. Heroes' Realm and Demon Tower both entertain me, regardless of engine.
XP/VX are both SO much easier to balance though - I've tried the trials, and I like what I've seen.
EDIT: Basically, as long as the balance and the numbers are competant, and there's charm present, I'm not worried about the engine.
I've found, though, that with XP/VX my pen-and-pencil designs are easier to realize, and it's got built-in turn-based battles. With 2k3, it's so much easier to sprite resources, and plenty can be done to set a game apart in-engine.
So my final verdict is to stick with 2k3 until my current projects are done, and then move on.