Well.... I got bored and decided to edit the sprites a little bit, starting with the first character you play and her alternate outfits. I have to say, they do seem a bit better.

Before

After (but incomplete because of a thunderstorm that night)

I do have to say, she did get a bit brighter for players, even me.... wow.

so now I'm going to "bloom" all characters, including the RTP characters used, and this will take a while. I also have to finish her normal outfit, since the grey shown on her shirt, inside the lab coat, seems to be unfinished.